Electron microscopy image of myelinated axons with blue myelin and red cells

Hartley Lab Publications

Publications

  • Privitera, Cardaci, Zupan, Lucia Di Pietro, Carota, Sibbitts, Mangione, Graziani, Buccarello, Bellia, Di Pietro, Lazzarino, Lunte, Hartley, Caraci, Tavazzi, Maiani, Amorini, Lazzarino, Caruso. Carnosine protects human microglia against ABeta oligomers through a multimodal mechanism of action: inhibition of oxidative stress, rescue of cellular energy status, and enhancement of phagocytosis. Frontiers in Immunology. 2026. https://doi.org/10.3389/fimmu.2026.1768094
  • De Silva Mohotti, Williams, Binjawadagi, Kobayashi, Dedunupitiya, Petersen, Garcia, Hartley. Temporal dynamics of CNS cholesterol esters correlate with demyelination and remyelination. ACS Chemical Neuroscience. 2026. https://doi.org/10.1021/acschemneuro.5c00703
  • Escobar, De Silva Mohotti, Manolescu, Radadiya, Dhar, Hartley.Reduced cholesterol alters the biophysical properties of repaired myelin. BBA - Mol Cell Biol Lipids. 2025. https://doi.org/10.1016/j.bbalip.2025.159637
  • Cardaci, Di Pietro, Zupan, Sibbits, Privitera, Lunte, Caraci, Hartley, Caruso. Characterizing oxidative stress induced by Aβ oligomers and the protective role of carnosine in primary mixed glia cultures. Free Rad Biol Med. 2025. https://doi.org/10.1016/j.freeradbiomed.2025.01.030
  • De Silva Mohotti, Kobayashi, Williams, Binjawadagi, Evertsen, Christ, Hartley. Lipidomic analysis reveals differences in the extent of remyelination in the brain and spinal cord. J Proteome Res. 2023. https://doi.org/10.1021/acschemneuro.5c00703
  • Hartley, Galton. ATA Centennial Interview Series: Thyroid Hormone Metabolism—A Historical Perspective. Thyroid. 2023. https://doi.org/10.1089/ve.2023.0002
  • Hartley, Shokat, DeBell, Banerji, Kirkemo, Scanlan. Pharmacological Complementation Remedies an Inborn Error of Lipid Metabolism. Cell Chemical Biology. 2020. https://doi.org/10.1016/j.chembiol.2020.02.008
  • Hartley, Banerji, Tagge, Kirkemo, Chaudhary, Calkins, Galipeau, Shokat, DeBell, VanLeuven, Marracci, Pocius, Banerji, Ferrara, Meinig, Emery, Bourdette, Scanlan. Myelin repair stimulated by CNS-selective thyroid hormone action. JCI Insight. 2019. https://doi.org/10.1172/jci.insight.126329
  • Barez-Lopez, Hartley, Grijota-Martinez, Scanlan, Guadano-Ferraz. Sobetirome and its Amide Prodrug Sob-AM2 Exert Thyromimetic Actions in Mct8-Deficient Brain. Thyroid. 2018. https://doi.org/10.1089/thy.2018.0008
  • Hartley, Kirkemo, Banerji, Scanlan. A Thyroid Hormone-Based Strategy for Correcting the Biochemical Abnormality in X-Linked Adrenoleukodystrophy. Endocrinology. 2017. https://doi.org/10.1210/en.2016-1842
  • Ferrara, Meinig, Placzek, Banerji, McTigue, Hartley, Sanford-Crane, Banerji, Bourdette, Scanlan. Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration. Bioorganic & Medicinal Chemistry. 2017. https://doi.org/10.1016/j.bmc.2017.03.047
  • Placzek, Ferrara, Hartley, Sanford-Crane, Meinig, Scanlan. Sobetirome prodrug esters with enhanced blood-brain barrier permeability. Bioorganic & Medicinal Chemistry. 2016. https://doi.org/10.1016/j.bmc.2016.09.038
  • Hartley, Altowaijri, Bourdette. Remyelination and multiple sclerosis: therapeutic approaches and challenges. Current Neurology and Neuroscience Reports. 2014. https://doi.org/10.1007/s11910-014-0485-1
  • Hartley, Schneggenburger, Imperiali. Lipid bilayer nanodisc platform for investigating polyprenol-dependent enzyme interactions and activities. PNAS. 2013. https://doi.org/10.1073/pnas.1320852110
  • Hartley, Imperiali. At the membrane frontier: a prospectus on the remarkable evolutionary conservation of polyprenols and polyprenyl-phosphates. Archives of Biochemistry and Biophysics. 2012. https://doi.org/10.1016/j.abb.2011.10.018
  • Hartley, Morrison, Aas, Borud, Koomey, Imperiali. Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N’-diacetylbacillosamine. Biochemistry. 2011. https://doi.org/10.1021/bi2003372
  • Borud, Viburiene, Hartley, Paulsen, Egge-Jacobsen, Imperiali, Koomey. Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system. PNAS. 2011. https://doi.org/10.1073/pnas.1103321108
  • Hartley, Larkin, Imperiali. Chemoenzymatic synthesis of polyprenyl phosphates. Bioorganic & Medicinal Chemistry. 2008. https://doi.org/10.1016/j.bmc.2008.03.025

Highlighted Publications